Occasional reflections on Life, the World, and Mathematics

Posts tagged ‘genetics’

Your shadow genetic profile

So, the “Golden Gate killer” has been caught, after forty years. Good news, to be sure, and it’s exciting to hear of the police using modern data systems creatively:

Investigators used DNA from crime scenes that had been stored all these years and plugged the genetic profile of the suspected assailant into an online genealogy database. One such service, GEDmatch, said in a statement on Friday that law enforcement officials had used its database to crack the case. Officers found distant relatives of Mr. DeAngelo’s and, despite his years of eluding the authorities, traced their DNA to his front door.

And yet… This is just another example of how all traditional notions of privacy are crumbling in the face of the twin assaults from information technology and networks. We see this in the way Facebook generates shadow profiles with information provided by your friends and acquaintances, even if you’ve never had a Facebook account. It doesn’t matter how cautious you are about protecting your own data: As long as you are connected to other people, quite a lot can be inferred about you from your network connections, or assembled from bits that you share with people to whom you are connected.

Nowhere is this more true than with genetic data. When DNA identification started being used by police, civil-liberties and privacy activists in many countries forced stringent restrictions on whose DNA could be collected, and under what circumstances it could be kept and catalogued. But now, effectively, everyone’s genome is public. It was noticed a few years back that it was possible to identify (or de-anonymize) participants in the Personal Genome Project, by drawing on patterns of information in their phenotypes. Here’s a more recent discussion of the issue. But those people had knowingly allowed their genotypes to be recorded and made publicly available. In the Golden Gate Killer case we see that random samples of genetic material can be attributed to individuals purely based on their biological links to other people who volunteered to be genotyped.

The next step will be, presumably, “shadow genetic profiles”: A company like GEDmatch — or the FBI — could generate imputed genetic profiles for anyone in the population, based solely on knowledge of their relationships to other people in their database, whether voluntarily (for the private company) or compulsorily (FBI).

Neanderthal science

I just listened to all of a two-hour discussion between journalist Ezra Klein and professional atheist Sam Harris, about Harris’s defense of the right-wing policy entrepreneur (as Matthew Yglesias has described him) Charles Murray, famous for his racist application of intelligence research to public policy, most famously in a notorious chapter of his book The Bell Curve. Klein pushes back effectively against Harris’s self-serving martyrdom — Harris, not unreasonably, identifies with the suffering of a wealthy and famous purveyor of quack science whose livelihood is ever-so-slightly harmed by public criticism* — but he doesn’t sufficiently engage, I think, with Harris’s contention that he is promoting the values of real science. Unfortunately, the “mainstream social science” that Harris and Murray are promoting exists only in secret messages from “reputable scientists in my inbox, who have totally taken my side in this, but who are too afraid to say so publicly”. Harris doesn’t allow for a second that there is any good-faith argument on the other side. Anyone who disagrees is merely trying to shut down scientific progress, or simply confusing scientific truth with do-gooding wishful thinking.

The truth of the matter is, Murray and other brave seekers of truth are doing the opposite of helping to clarify reality. They are wading into a swamp of confusion, and pulling out some especially stinky slime that they can hurl at disfavoured groups.

As much as Harris tries to promote Murray as a pure-hearted “content-of-our-character” anti-racist individualist, as long as “race” exists as a social factor affecting people’s self-image, the communities they belong to, and the way they are perceived by others, it remains a potent social force. When demographers argue that “race” isn’t “real”, they are saying that racial categories don’t separate natural clusters by genetic or physical traits. When Murray says, let’s stop talking about race, let’s talk about individual genetic endowments, he is saying that racial groupings have no causal effect on their own, but only label clusters whose difference arise from deep physical causes — wrong on both sides. (more…)

The biggest genetics-investment opportunity ever!

I was just looking at this paper from 2012, that purports to discover the heritability of economic and political preferences by slightly shady statistical analysis of GWAS data. And then it hit me: We could market

An investment plan tailored to YOUR genotype

Okay, we’ll have to work on the catchphrase. Feel free to send your seed money. (The genotype-based diet is running like gangbusters.) Excuse me while I go off for a moment to write the patent application.


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